Jay and Silent Bob, the popular drug dealer characters from Kevin Smith's movies, appear as tourists visiting Sunrise Studios who spot Gail Weathers and mistake her for Connie Chung.
The producer played by Lance Henriksen has a skeletal robot in his office that bears a slight resemblance to the T-800 in Terminator, The (1984), in which Henriksen co-starred.
The empty cinematographer's chair on the "Stab 3" set has the name of the actual Scream 3 cinematographer, Peter Deming.
Throughout the movie the actors and actresses complain about the rewrites and the 3 different scripts for Stab 3. These complaints actually originated with the cast of Scream 3, because of frequent rewrites and 3 different endings.
Set a record in its opening weekend for number of screens in the U.S.: 3,467.
There is a Creed poster in Sidney's room on the movie set. Creed is on the Scream 3 soundtrack.
A special makeup-effects man working with "Tyson" on the set of Stab 3 is named Stan, a possible reference to legendary makeup-FX man Stan Winston.
Gale mentions Jennifer's relationship with Brad Pitt. Courtney Cox's "Friends" (1994) costar Jennifer Aniston is married to Brad Pitt.
The house used during the climax, where most of the killing takes place, is the same house used as a school in Halloween H20: Twenty Years Later.
The cyborg skeleton model seen in Lance Henriksen's office is a reference to Aliens and Alien3 in which he plays a cyborg.