| Dewey Riley, played by David Arquette |
| Dewey has left Woodsboro behind to work as the technical advisor on "Stab 3". He has also cultivated a cozy relationship with actress Jennifer Jolie. |
| Sidney Prescott, played by Neve Campbell |
| A more mature Sidney has settled into a life of quiet seclusion in Northern California, but the terrifying events that envelope the "Stab 3" production ultimately draw her out of hiding. |
| Gale Weathers, played by Courteney Cox Arquette |
| Gale is at the pinnacle of her career as a hotshot TV personality and makes no apologies for her methods. The breaking news on the "Stab 3" set could take her career to a brand new level. |
| Mark Kincaid, played by Patrick Dempsey |
| When a homicide involves the movie business, LAPD Detective Mark Kincaid catches the case. For him, Hollywood is all about ghosts. |
| Roman Bridger, played by Scott Foley |
| On the cusp of his 30th birthday, director Roman Bridger is making the leap from music videos to feature films. But he comes to believe that someone is trying to kill his movie, "Stab 3". |
| John Milton, played by Lance Henriksen |
| Producer John Milton, the mastermind behind the "Stab" franchise, has been making horror movies for 30 years. His Hollywood Hills mansion has seen even more action than his sets. |
| Tom Prinze, played by Matthew Keeslar |
| Tom is the tall, lanky and self-assured actor cast as Dewey Riley in "Stab 3". |
| Sarah Darling, played by Jenny McCarthy |
| A "starlet" for more than a decade, Sarah has had it with bimbo roles. But what's a voluptuous blonde to do? |
| Angelina Tyler, played by Emily Mortimer |
| Plucked from a group of 50,000 hopefuls for the role of Sidney in "Stab 3", Angelina is an ingenue living the Hollywood dream. But how did she really get the part? |
| Jennifer Jolie, played by Parker Posey |
| Method actress Jennifer Jolie digs deep to give her portrayal of Gale Weathers just the right edge in "Stab 3". She's convinced "her" Gale knows best when the going gets rough on-set. |
| Tyson Fox, played by Deon Richmond |
| Actor Tyson Fox has few illusions about Hollywood, but still has dreams. Yes, his character in "Stab 3" works in a video store like Randy Meeks, but Tyson is determined to make him his own. |
| Steve Stone, played by Patrick Warburton |
| Steven Stone protects all the big celebrities. But nothing has prepared him or client Jennifer Jolie for the events on the set of "Stab 3". |
| Cotton Weary, played by Liev Schreiber |
| Once upon a time, Cotton just wanted 15 minutes of fame. Now the former prison inmate, unjustly accused of murder, hosts a nationally syndicated television show -- 100% Cotton. |